TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 0.340nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of recombinant human EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate incubate for 15 mins by LANCE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human YES using biotinyl-beta Abeta-Abeta AYQAEENTYDEYEN as substrate incubate for 30 mins by LANCE assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Inhibition of Her2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Inhibition of ErBB2 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human HDAC1 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant LYN using biotinyl-beta amyloid beta amyloid beta AKVEKIGEGTYGVVYK as substrate measured after 120 mins in the presen...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD measured after 15 mins in the presence of ATP by LANCE methodMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human JAK3 using Ulight-CAGAGAIETDKEYYTVKD as substrate incubate for 60 mins by LANCE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant JAK3 using Ulight-CAGAGAIETDKEYYTVKD measured after 60 mins in the presence of ATP by LANCE methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, PR China.
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant HER2 using biotinyl-beta amyloid beta amyloid beta AAEEEEYFELVAKKK measured after 10 mins in the presence of ATP by H...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of wild type EZH2 (unknown origin) in presence of 1 uM SAM by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant FGR using Ulight-TK peptide as substrate measured after 60 mins in the presence of ATP by LANCE methodMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant LCK using Ulight-Poly GAT[EAY(1:1:1) as substrate measured after 10 mins in the presence of ATP by LANCE methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human HDAC1 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human LCK using Ulight-Poly GAT[EAY(1:1:1)]n as substrate incubate for 10 mins by LANCE assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant full length FAK incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant full length FAK incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting metho...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged BMX expressed in Sf21 cells preincubated for 5 mins followed by biotinyl-beta Abet...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant full length FAK incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting metho...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2JS9V99PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2JS9V99PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Sichuan University and Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair